Lymphocytes Definition - Morphologically, both T and B lymphocytes are small cells whose diameter (8–10mm unless activated) is comparable with that of large bacteria. They are spherical in shape and have a relatively large nucleus surrounded by a thin rim of cytoplasm. Organelles in resting lymphocytes are developed rather poorly. Electron microscopy reveals a number of microvilli on their surfaces.
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This ‘‘boring,’’ bland morphological pattern says virtually nothing about the complexity of the function that lymphocytes perform. Methods based on immunochemistry and molecular biology show that the surface of a lymphocyte contains thousands of different kinds of molecules, many of which serve as important intermediaries during antigen recognition, cellular activation, differentiation, and attack against antigens.
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